Early Detection and Treatment Evaluation of Gastric Cancer is a PhD dissertation carried out at Technical University of Munich, Germany. It is composed of useful literature reviews in introduction part, very brief and clear experimental set-ups in methodology part, graphs, tables and diagrams for original findings in result section and finally concise discussions and conclusions. Generally, the original investigation sheds light on two important challenges in the arena of gastric cancer investigation. First, it reveals the potential biomarker molecules (Cathepsins and MMPs) important for early detection of gastric cancer. Secondly, the potential resistance factors for gastric cancer against SAHA treatment have been also well investigated.This study, as an original work, can help the reader as a good resource to understand gastric carcinogenesis and potential molecular targets for early detection and treatment of gastric cancer.
The effect of centrally administered losartan, an angiotensin-2 receptor antagonist on gastric acid secretion and gastric cytoprotection was studied using different models of gastric ulcers such as acetic acid-induced chronic gastric ulcers, pylorus ligation, ethanol induced and stress induce acute gastric ulcer and cysteamine hydrochloride induced duodenal ulcer. Losartan was administered intracerebroventrically at two different doses of 125 micro gm/kg and 250 micro gm/kg. Both doses of losartan increased healing of ulcer in acetic acid induced chronic gastric ulcer model. In pylorus legated rats, a significant reduction in free acidity, total acidity and ulcer index was observed with high dose while low dose produced reduction in free acidity and ulcer index. Both doses also showed significant antiulcer effect in ethanol-induced and stress-induced gastric ulcers. Losartan also reduced ulcer area in cysteamine-induced duodenal ulcer. It was concluded that angiotensin II receptor antagonism in brain increases healing of gastric ulcers and also prevents development of gastric and duodenal ulcers in rats.
Authors- Jasneet Singh Bhullar MD,MS; Sandiya Bindroo MD; Neha Varshney MD; Vijay Mittal MD, FACS. - Gastric cancer remains one of the leading causes of malignancy-related deaths worldwide. There is extensive ongoing research for a better understanding of the gastric cancer pathology and finding newer treatments. This book summarizes the different relevant topics on gastric cancer in which strides of improvement have been achieved. The current statuses and the advancements on different aspects of gastric cancer research, diagnosis, staging and treatments are discussed.
The present work deals with the antisecretory and gastroprotective effect of selenomethionine in swiss albino rat system by using 1. 4 hour Pylorus ligation model for antisecretory activity using the following pathophysiological and biochemical parameters in gastric juice and gastric mucosa a) Ulcer index measurement of the glandular portion of the stomach, b) Measurement of volume, pH, free and total acidity, peptic activity, DNA content of the gatsric juice and c) Total protein, carbohydrate estimation in gastric juice and gastric mucosa, 2. ethanol induced gastric ulcer model using a)Ulcer index measurement,b) Gastric wall mucous content estimation and c)Lipid peroxide level estimation, 3. stress induced ulcer model using a) Measurement of ulcer index, b)Estimation of gastric wall mucus content and 4. Aspirin induced gastric ulcer model of ulcer index measurement. Antiulcer and cytoprotective effect of Selenomethionine and reference drug Cemetidine in rats are studied in the above validated gastric ulcer models after a desired period of drug administration. This work works at the development of a novel gastroprotective molecule.
The tasks of achieving efficient delivery of drugs that have poor bioavailability or narrow absorption window have plagued the pharmaceutical research scientists for decades. Thus, much research has been dedicated to the development of novel polymeric based gastroretentive drug delivery systems that may optimize the bioavailability and subsequent therapeutic efficacy of such drugs. An effective approach of achieving this is through the prolongation of the gastric residence time employing several gastroretentive drug delivery mechanisms. Of these various approaches tried, gastric floating drug delivery systems have lower bulk density than gastric fluids and therefore remain buoyant on the stomach contents. These systems are generally not affected by the gastric emptying rate. They are gaining importance due to improvement in the bioavailability and their convenience of large scale manufacture because many of these dosage forms are tablets.
Background & Objective: Since calcium has got importance in physiology and the objective of the present study is to study the effect of different calcium channel blockers through i.c.v administration on gastric and duodenal ulcers. Methods: The effect of different calcium channel blockers on gastric and duodenal ulcers were evaluated by using different experimental models such as acetic acid induced chronic gastric ulcer, pylorus ligation induced gastric ulcers, ethanol induced gastric ulcers, stress induced gastric ulcers, and cysteamine induced duodenal ulcers. In all these models the common parameter determined was ulcer index. Results: The nickel salt and verapamil a significant effect on ulcer healing in acetic acid induced ulcer model, ?-agatoxin did not show any significant effect on ulcer healing. The treatment groups showed a significant reduction in ulcer index in other models. Only ?-agatoxin did not showed significant increase in mucin compared to other treatment groups.
DO YOU WANT TO LOSE WEIGHT? HAVE YOU TRIED DIETS AND FAILED? DO YOU WANT A COMPLETELY NEW APPROACH? A Gastric Band is a radical, surgical operation that reduces the available space in the stomach. Paul McKenna’s Hypnotic Gastric Band is a psychological procedure that can help to convince the unconscious mind that a gastric band has been fitted, so the body behaves exactly as if it were physically present. HOW DOES IT WORK? Along with the book, the system contains a hypnosis CD and an instructional DVD to provide complete support for physical and psychological change whilst you lose weight. There’s no physical surgery, no scarring and no forbidden foods. Just follow all the instructions and let Paul help you lose weight.
Ucn/CRF-R2 system in the upper GI tract ( mainly the stomach plays a completely different role in gastric inflammatory response and motility compared with that of the Ucn/CRF-R1 in the lower GI tract (colon). In the stomach peripheral stimulation of CRFR2 can protect the stomach from stress induced ulceration. Peripheral stimulation of CRFR2 in the stomach inhibits its motility producing gastric stasis. The stimulation of peripheral CRFR2 by specific agonists will be helpful in the treatment of inflammatory condition of the stomach without interfering with colonic functions.
This book provides a statistical approach to design and optimization of monolithic gastric floating drug delivery system of anticancer drug, Alfuzosin. Drug delivery system has its main aim to administered appropriate amount of drugs to the target site of the body in order to achieve and maintain the desired therapeutic drug concentration that elicits the desired pharmacological action. Drug absorption of oral route could be inadequate and highly variable in individuals due to physiological variabilities. This can be overcome by developing a suitable gastroretentive drug delivery system, which can prolong the gastric residence time of dosage form thereby improve the drug bio-availability. Floating drug delivery system is considerably easy and logical approach in the development of gastroretentive dosage forms. The oral delivery of anticancer alfuzosin was facilitated by preparing a gastric floating dosage form which could increase its absorption in the gastric region of the stomach by prolonging the gastric residence time of the drug. In the present work, gastric floating tablets were optimized by conventional process and further optimized by statistical methods.
Floating drug delivery system or hydrodynamically balance systems have a bulk density lower than gastric fluid and thus remains buoyant in the stomach for a prolonged period of time without affecting the gastric emptying rate. While the system is floating on gastric contents the drug is released slowly at a desired rate from the system. After the release of drug residual system is emptied from the stomach. This results in increase in gastric residence time and a better control of fluctuation in plasma drug concentration. Development of oral controlled-release systems has been a challenge to formulation scientists because of their inability to restrain and localize the system in the targeted area of the gastrointestinal tract.