Fungi: Biology and Applications, Second Edition provides a comprehensive treatment of fungi, covering biochemistry, genetics and the medical and economic significance of these organisms at introductory level. With no prior knowledge of the subject assumed, the opening chapters offer a broad overview of the basics of fungal biology, in particular the physiology and genetics of fungi and also a new chapter on the application of genomics to fungi. Later chapters move on to include more detailed coverage of topics such as antibiotic and chemical commodities from fungi, new chapters on biotechnological use of fungal enzymes and fungal proteomics, and fungal diseases of humans, antifungal agents for use in human therapy and fungal pathogens of plants.
Examines effects of the environmental distribution of antimicrobial resistance genes on human health and the ecosystem Resistance genes are everywhere in nature—in pathogens, commensals, and environmental microorganisms. This contributed work shows how the environment plays a pivotal role in the development of antimicrobial resistance traits in bacteria and the distribution of resistant microbial species, resistant genetic material, and antibiotic compounds. Readers will discover the impact of the distribution in the environment of antimicrobial resistance genes and antibiotics on both the ecosystem and human and animal health. Antimicrobial Resistance in the Environment is divided into four parts: Part I, Sources, including ecological and clinical consequences of antibiotic resistance by environmental microbes Part II, Fate, including strategies to assess and minimize the biological risk of antibiotic resistance in the environment Part III, Antimicrobial Substances and Resistance, including antibiotics in the aquatic environment Part IV, Effects and Risks, including the effect of antimicrobials used for non-human purposes on human health Recognizing the intricate links among overlapping complex systems, this book examines antimicrobial resistance using a comprehensive ecosystem approach. Moreover, the book's multidisciplinary framework applies principles of microbiology, environmental toxicology, and chemistry to assess the human and ecological risks associated with exposure to antibiotics or antibiotic resistance genes that are environmental contaminants. Each chapter has been written by one or more leading researchers in such fields as microbiology, environmental science, ecology, and toxicology. Comprehensive reference lists at the end of all chapters serve as a gateway to the primary research in the field. Presenting and analyzing the latest findings in a field of growing importance to human and environmental health, this text offers readers new insights into the role of the environment in antimicrobial resistance development, the dissemination of antimicrobial resistant genetic elements, and the transport of antibiotic resistance genes and antibiotics.
Governments around the world are passing laws requiring industry to assess the toxicity of the chemicals and products they produce, but to do so while reducing, refining, or even replacing testing on animals. To meet these requirements, experimental toxicologists and risk assessors are adopting quantitative approaches and computer simulations to study the biological fate and effects of chemicals and drugs. In Quantitative Modeling in Toxicology leading experts outline the current state of knowledge on the modeling of dose, tissue interactions and tissue responses. Each chapter describes the mathematical foundation, parameter estimation, challenges and perspectives for development, along with the presentation of a modeling template. Additionally, tools and approaches for conducting uncertainty, sensitivity and variability analyses in these models are described. Topics covered include: the quantitative models of pharmacokinetics of individual chemicals and mixtures models for toxicant-target tissue interaction. models for cellular, organ, and organism responses. approaches, tools and challenges for model application and evaluation A website containing computer codes accompanies the book to help the reader reconstruct the models described and discussed in the various chapters. Quantitative Modeling in Toxicology serves as an essential reference source and tool box for risk assessors and researchers and students in toxicology, public health, pharmacology, and human toxicology interested in developing quantitative models for a better understanding of dose-response relationships.
The control of diseases in crops is still largely dominated by the use of fungicides, but with the increasing incidence of fungicide resistance, plus mounting concern for the environment resulting from excessive agrochemical use, the search for alternative, reliable methods of disease control is gaining momentum. The purpose of this important book is to examine the development and exploitation (or potential for exploitation) of a range of non-chemical approaches to disease control, with a focus on the need for a greater understanding of crop ecology as the basis for effective disease control in the field. Chapters in the book, written by international experts in the subject area, include coverage of: biological control methods host-plant resistance the exploitation of tolerance and the use of bacteriophages Carefully edited by Professor Dale Walters, widely respected for his work in the area of crop protection, Disease Control in Crops is an essential reference book for plant pathologists, microbiologists, plant and agricultural scientists and crop protection specialists, including those working within, and providing consultancy to, the agrochemical industries. Libraries in all universities and research establishments where biological sciences and agriculture are studied and taught should have copies of this timely publication on their shelves.
While numerous books have been written on earthquakes, earthquake resistance design, and seismic analysis and design of structures, none have been tailored for advanced students and practitioners, and those who would like to have most of the important aspects of seismic analysis in one place. With this book, readers will gain proficiencies in the following: fundamentals of seismology that all structural engineers must know; various forms of seismic inputs; different types of seismic analysis like, time and frequency domain analyses, spectral analysis of structures for random ground motion, response spectrum method of analysis; equivalent lateral load analysis as given in earthquake codes; inelastic response analysis and the concept of ductility; ground response analysis and seismic soil structure interaction; seismic reliability analysis of structures; and control of seismic response of structures. Provides comprehensive coverage, from seismology to seismic control Contains useful empirical equations often required in the seismic analysis of structures Outlines explicit steps for seismic analysis of MDOF systems with multi support excitations Works through solved problems to illustrate different concepts Makes use of MATLAB, SAP2000 and ABAQUAS in solving example problems of the book Provides numerous exercise problems to aid understanding of the subject As one of the first books to present such a comprehensive treatment of the topic, Seismic Analysis of Structures is ideal for postgraduates and researchers in Earthquake Engineering, Structural Dynamics, and Geotechnical Earthquake Engineering. Developed for classroom use, the book can also be used for advanced undergraduate students planning for a career or further study in the subject area. The book will also better equip structural engineering consultants and practicing engineers in the use of standard software for seismic analysis of buildings, bridges, dams, and towers. Lecture materials for instructors available at www.wiley.com/go/dattaseismic
This book, which is the translated version of a Swedish book, combines a general introduction of a variety of antibiotics with a more in-depth discussion of resistance. The focus on resistance in learning about antibiotics will help future scientists recognize the problem antibiotics resistance poses for medicinal and drug-related fields, and perhaps trigger more research and discoveries to fight antibiotic resistant strains. Current overviews of the topic are included, along with specific discussions on the individual mechanisms (betalactams, glycopeptides, aminoglycosides, etc) used in various antibacterial agents and explanations of how resistances to those develop. Methods for counteracting resistance development in bacteria are discussed as well.
A Timely Exploration of Multiuser Detection in Wireless Networks During the past decade, the design and development of current and emerging wireless systems have motivated many important advances in multiuser detection. This book fills an important need by providing a comprehensive overview of crucial recent developments that have occurred in this active research area. Each chapter is contributed by noted experts and is meant to serve as a self-contained treatment of the topic. Coverage includes: Linear and decision feedback methods Iterative multiuser detection and decoding Multiuser detection in the presence of channel impairments Performance analysis with random signatures and channels Joint detection methods for MIMO channels Interference avoidance methods at the transmitter Transmitter precoding methods for the MIMO downlink This book is an ideal entry point for exploring ongoing research in multiuser detection and for learning about the field's existing unsolved problems and issues. It is a valuable resource for researchers, engineers, and graduate students who are involved in the area of digital communications.
The detection and evaluation of adverse drug reactions is crucial for understanding the safety of medicines and for preventing harm in patients. Not only is it necessary to detect new adverse drug reactions, but the principles and practice of pharmacovigilance apply to the surveillance of a wide range of medicinal products. Stephens' Detection and Evaluation of Adverse Drug Reactions provides a comprehensive review of all aspects of adverse drug reactions throughout the life cycle of a medicine, from toxicology and clinical trials through to pharmacovigilance, risk management, and legal and regulatory requirements. It also covers the safety of biotherapeutics and vaccines and includes new chapters on pharmacogenetics, proactive risk management, societal considerations, and the safety of drugs used in oncology and herbal medicines. This sixth edition of the classic text on drug safety is an authoritative reference text for all those who work in pharmacovigilance or have an interest in adverse drug reactions, whether in regulatory authorities, pharmaceutical companies, or academia. Praise for previous editions "This book presents a comprehensive and wide-ranging overview of the science of pharmacovigilance. For those entering or already experienced in the pharmaceutical sciences, this is an essential work.” – from a review in E-STREAMS «…a key text in the area of pharmacovigilance…extensively referenced and well-written…a valuable resource…» – from a review in The Pharmaceutical Journal
Molecular Plant Immunity provides an integrated look at both well-established and emerging concepts in plant disease resistance providing the most current information on this important vitally important topic within plant biology. Understanding the molecular basis of the plant immune system has implications on the development of new varieties of sustainable crops, understanding the challenges plant life will face in changing environments, as well as providing a window into immune function that could have translational appeal to human medicine. Molecular Plant Immunity opens with chapters reviewing how the first line of plant immune response is activated followed by chapters looking at the molecular mechanisms that allow fungi, bacteria, and oomycetes to circumvent those defenses. Plant resistance proteins, which provide the second line of plant immune defense, are then covered followed by chapters on the role of hormones in immunity and the mechanisms that modulate specific interaction between plants and viruses. The final chapters look at model plant-pathogen systems to review interaction between plants and fungal, bacterial, and viral pathogens. Written by a leading team of international experts, Molecular Plant Immunity will provide a needed resource to diverse research community investigated plant immunity.
This pocket reference and revision guide is a must for all medical students and junior doctors preparing for major exams in clinical medicine or needing a rapid reminder of essential facts during a clinical attachment. Now thoroughly updated, this new edition combines the first editions of Rapid Medicine and Rapid Differential Diagnosis and contains reference to over 200 common medical conditions and diseases and 350 signs and symptoms encountered on a daily basis on the wards, in clinics and in exams. This concise, no-nonsense reference is presented in an A-Z format for easy access to information, and includes a thematic index with conditions sorted by speciality making it an ideal companion in any clinical situation.
Surveying and comparing all techniques relevant for practical applications in surface and thin film analysis, this second edition of a bestseller is a vital guide to this hot topic in nano- and surface technology. This new book has been revised and updated and is divided into four parts – electron, ion, and photon detection, as well as scanning probe microscopy. New chapters have been added to cover such techniques as SNOM, FIM, atom probe (AP),and sum frequency generation (SFG). Appendices with a summary and comparison of techniques and a list of equipment suppliers make this book a rapid reference for materials scientists, analytical chemists, and those working in the biotechnological industry. From a Review of the First Edition (edited by Bubert and Jenett) «… a useful resource…» (Journal of the American Chemical Society)
Modelling of Engineering Materials presents the background that is necessary to understand the mathematical models that govern the mechanical response of engineering materials. The book provides the basics of continuum mechanics and helps the reader to use them to understand the development of nonlinear material response of solids and fluids used in engineering applications. A brief review of simplistic and linear models used to characterize the mechanical response of materials is presented. This is followed by a description of models that characterize the nonlinear response of solids and fluids from first principles. Emphasis is given to popular models that characterize the nonlinear response of materials. The book also presents case studies of materials, where a comprehensive discussion of material characterization, experimental techniques and constitutive model development, is presented. Common principles that govern material response of both solids and fluids within a unified framework are outlined. Mechanical response in the presence of non-mechanical fields such as thermal and electrical fields applied to special materials such as shape memory materials and piezoelectric materials is also explained within the same framework.
Disasters threaten all parts of the world and they appear to be increasing in frequency, scale and intensity. Despite huge improvements in the emergency response, permanent reconstruction is often uncoordinated, inefficiently managed and slow to begin. International agencies are geared to an efficient response in terms of humanitarian relief, but they are not well versed in the requirements of long-term reconstruction, which is often constrained by lack of planning and poorly coordinated management. The construction industry is typically engaged in a range of critical activities after a disaster, including provision of temporary shelter in the immediate aftermath and restoration of permanent shelter and public infrastructure once the immediate humanitarian needs have been attended to. Post-Disaster Reconstruction of the Built Environment identifies the challenges that face the industry and highlights best practice to enable the construction industry to address those problems which make an effective response to these unexpected events difficult. Written by an international team of experts, this book will help researchers and advanced students of construction understand the problems faced by communities and the construction industry when faced with a natural or man-made disaster, and identify the planning and management processes required by the industry to mount an effective response.
This book presents a comprehensive and substantial overview of the emerging field of food safety engineering, bringing together in one volume the four essential components of food safety: the fundamentals of microbial growth food safety detection techniques microbial inactivation techniques food safety management systems Written by a team of highly active international experts with both academic and professional credentials, the book is divided into five parts. Part I details the principles of food safety including microbial growth and modelling. Part II addresses novel and rapid food safety detection methods. Parts III and IV look at various traditional and novel thermal and non-thermal processing techniques for microbial inactivation. Part V concludes the book with an overview of the major international food safety management systems such as GMP, SSOP, HACCP and ISO22000.